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The cyclic synthesis and APC/C-mediated (Anaphase-Promoting Complex/Cyclosome) destruction of the different CYCs right after completion of their function, implying deactivation of their CDK partners, drives advancement through the cell cycle

As a consequence, an increase in serum insulin levels was observed, with a significantly higher peak level at 60 min (obesity) and 30 min (normal weight)

This finding strongly supports the necessity of RAMP1 and RAMP3 for mediating cagrilintide-induced weight loss through AMY1R and AMY3R signaling [2]